Description
What are CJC-1295 and ipamorelin?
CJC-1295 and ipamorelin belong to a category of synthetic therapeutic peptides called growth hormone secretagogues, or substances that promote the secretion of growth hormone. Growth hormone, for its part, increases cellular replication, encourages collagen synthesis in your skeletal muscles, and stimulates the production of a separate hormone called insulin-like growth factor-1 (IGF-1), which helps regulate the process by which your body creates fat.1 2 3 Given these qualities, a higher concentration of circulating growth hormone can lead to improved exercise training, increased muscle strength, and a decreased propensity for fat accumulation.4
Despite belonging to the same category and effecting a common outcome, CJC-1295 and ipamorelin have distinct mechanisms of action:
CJC-1295’s mechanism of action
CJC-1295 mimics a chemical from the hypothalamus called growth hormone-releasing hormone (GHRH), which tells the pituitary gland to release growth hormone.5
Ipamorelin’s mechanism of action
Ipamorelin is an analog of ghrelin, a hormone originating from the cells in your stomach.6 As such, it binds to the brain’s ghrelin receptor and, like GHRH, stimulates growth hormone secretion from the pituitary. Importantly, its secretagogue action is selective, having no effect on stress hormones like cortisol, an overpresence of which can cancel your efforts to gain muscle or shed fat.7 8
Why are CJC-1295 and ipamorelin used together?
CJC-1295 and ipamorelin are commonly used together because they have complementary time-release characteristics:
- CJC-1295 is effectively GHRH that has been modified to have a longer half-life, so it stimulates pituitary growth hormone secretion in a sustained manner over an extended period.9
- Ipamorelin acts on the pituitary gland directly, inducing a more immediate dump of growth hormone into circulation.
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