Description
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded by your mitochondrial DNA. Known as an “exercise mimetic,” it plays a crucial role in cellular metabolism, energy production, and metabolic flexibility.
Core Benefits
Metabolic Boost: Acts on the AMP-activated protein kinase (AMPK) pathway to increase fat burning and glucose uptake.
Exercise Mimicry: Promotes many of the same adaptations as intense workouts, such as improved insulin sensitivity and physical endurance.
Stress Resistance: Helps cells survive and adapt under metabolic or oxidative stress.
How It Works
Unlike most peptides that act directly as hormones, MOTS-c works at the genetic level. When your cells are stressed (such as during exercise or fasting), MOTS-c translocates into the cell nucleus to regulate gene expression. It suppresses inflammation, improves mitochondrial function, and enhances your body’s ability to produce antioxidant.
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